Which statement about VariZIG (varicella immune globulin) is correct?

• A. It is effective if given after disease onset.
• B. It is the preferred treatment for varicella in all children.
• C. It is not effective after disease has progressed.
• D. It cures varicella rapidly.

Answer: (C)

VariZIG provides passive antibodies after varicella exposure to protect people who are not immune and are at high risk. It works to prevent infection or lessen its severity when given soon after exposure, but it is not a treatment for disease that has already started. Once varicella has progressed, the virus is actively replicating and immune globulin cannot reverse the illness; antiviral therapy and supportive care are used instead. So the statement that VariZIG is not effective after disease has progressed correctly reflects its role as post-exposure prophylaxis, not a cure or treatment for established varicella.